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Studies

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Published research and studies help us communicate the efficacy and safety of our products. Please check back often as we will be adding studies as they are published.

Cavibloc Studies: 

Antibacterial Compounds from Glycyrrhiza Uralensis

(From the Journal of Natural Products) 

Glycyrrhiza uralensis, widely recognized as Chinese licorice, has been used in traditional medicine and naturopathy for thousands of years. In this study, several compounds isolated from G. uralensis were tested against Streptococcus mutans, a bacteria largely responsible for tooth decay.  

The study found that Glycyrrhizol A showed antibacterial properties against S. mutans, while Glycyrrihol B and isoflavanoid gancaonin G also showed moderate antibacterial results.

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Effectiveness of a Novel Delivery System on Salivary Flow Rate, Quality of Life, and Inhibition of Caries Microbiota in Sjögren's Syndrome Patients

(University of Toronto)

Sjögren's Syndrome is an auto immune disease, marked by an occurrence of dry mouth and lack of saliva production. Patients with Sjögren's Syndrome were recruited, and instructed to consume two lollipops a day. Some contained xylitol, some contained licorice root extract, and some contained an artificial sweetener.  

The study has so far found that patients who used the lollipops increased saliva production even after the 10-day course, and some patients showed a lowered bacterial count.

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Anti-Cavity Effects of Licorice Root

(Licorice Lollipops and Oral Bateria)

In a pilot study researchers gave a small group of children sugar-free lollipops that contained a licorice extract. They found that when children at high risk for cavities sucked two lollipops a day for three weeks, the level of Streptocococcus mutans in their saliva was greatly decreased. The bacterial population stayed at a decreased level for twenty two days after the last lollipop was sucked and then began to increase again.  

In another pilot study using licorice lollipops, the licorice extract in the lollipops was rich in a substance called glycyrrhizol A. In this study people of different ages sucked two lollipops a day for ten days. Many of the people (but not all of them) showed a big decrease in Strepto-coccus mutans in their saliva after the lollipop treatment.  

Other research suggests that licorice root extracts can reduce the inflammation involved in periodontal disease and even inhibit the bone loss that occurs in the disease.

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Antibacterial Compounds in Licorice Root

(University of Toronto)

According to the research published in the American Chemical Society two antibacterial ingredients in licorice root are licoricidin and licorisoflavan A. The researchers discovered that each chemical strongly inhibited two major tooth decay bacteria – Streptococcus mutans, which is the most important bacterium involved in human tooth decay, and Streptococcus sobrinus. The chemicals also had a major inhibitory effect on two common gum disease bacteria – Porphyromonas gingivalis and Prevotella intermedia. In addition, the licoricidin moderately inhibited a third bacterium, Fusobacterium nucleatum, which is often associated with periodontal disease.

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